The Du Mai meridian is opened by Small Intestine 3; this meridian governs the Qi of all the yang meridians, as well as Bladder 62, which is the Yang Giao Mai meridian. This meridian pair is effective in treating stiffness in the shoulder, neck and back, and also regulates the inner canthus of the eye. When this coupling of meridians is utilized in treatment, the entire spine is addressed. It also nourishes the brain, and treats dizziness and tinnitus. On an energetic level, the Du relates to transformational cycles, survival issues, and groundedness in the world. Psychospiritually, issues of becoming "upright" and independent, as well as risk-taking, are relevant.